Issue 1, 2017

Thiophene-derived polymer dots for imaging endocytic compartments in live cells and broad-spectrum bacterial killing

Abstract

In this work, we present a new type of polymer dot synthesized from bithiophene (pTh-Pdot) via a simple and high yield procedure. Owing to their high brightness, excellent photo-stability, good biocompatibility, and molecular size, pTh-Pdots are promising for bioimaging applications. As a proof-of-concept demonstration, pTh-Pdots are herein employed to track the endocytic pathway in live cells. Furthermore, we show that these polymeric nanoparticles can serve as potent antibacterial agents by making use of their ability to disrupt bacterial membranes and high peroxidase mimicking activity.

Graphical abstract: Thiophene-derived polymer dots for imaging endocytic compartments in live cells and broad-spectrum bacterial killing

Supplementary files

Article information

Article type
Research Article
Submitted
25 Maijs 2016
Accepted
29 Jūn. 2016
First published
29 Jūl. 2016
This article is Open Access
Creative Commons BY license

Mater. Chem. Front., 2017,1, 152-157

Thiophene-derived polymer dots for imaging endocytic compartments in live cells and broad-spectrum bacterial killing

K. P. Prasad, A. Than, N. Li, M. Alam SK, H. Duan, K. Pu, X. Zheng and P. Chen, Mater. Chem. Front., 2017, 1, 152 DOI: 10.1039/C6QM00065G

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