Issue 34, 2017

Facile thiolation of hydroxyl functional polymers

Abstract

Sulfur is an important component in many biological systems. In the hands of an organic chemist it can provide an ample handle for a myriad of robust reactions including thiol–ene click chemistry. However, in polymer chemistry the thiol functionality is rarely attributed to the macromolecule due to unatainable synthetic protocols. Herein, we provide a simple and robust strategy to produce thiol-functional polymers. The chemistry capitalizes on an unsymmetrical disulfide that straightforwardly converts hydroxyl functional polymers to their thiolated counterpart. Finally, PEG hydrogels, using both thiol–ene and Michael addition, is used to showcase the possibilities presented by thiol functional polymers.

Graphical abstract: Facile thiolation of hydroxyl functional polymers

Supplementary files

Article information

Article type
Communication
Submitted
30 Jūn. 2017
Accepted
17 Jūl. 2017
First published
18 Jūl. 2017
This article is Open Access
Creative Commons BY license

Polym. Chem., 2017,8, 4996-5001

Facile thiolation of hydroxyl functional polymers

O. C. J. Andrén and M. Malkoch, Polym. Chem., 2017, 8, 4996 DOI: 10.1039/C7PY01097D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements