Issue 28, 2017

Is more better? A comparison of tri- and tetrapeptidic catalysts

Abstract

From an enzymatic perspective, there is a general notion that the bigger and more complex a catalytically active peptide is the more enzyme-like and the better it should become. But is this really true? We have tackled this question firstly by screening split-and-mix-libraries of tri- and tetrapeptides for members that catalyze aldol reactions. Then, the catalytic performance of all possible diastereoisomers of related tri- and tetrapeptidic catalysts of the type H-Pro-Pro-Glu/Asp-NH2 and H-Pro-Pro-Glu/Asp-Pro-NH2 in aldol and conjugate addition reactions was compared.

Graphical abstract: Is more better? A comparison of tri- and tetrapeptidic catalysts

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr. 2017
Accepted
20 Maijs 2017
First published
22 Maijs 2017

Org. Biomol. Chem., 2017,15, 5877-5881

Is more better? A comparison of tri- and tetrapeptidic catalysts

T. Schnitzer, M. Wiesner, P. Krattiger, J. D. Revell and H. Wennemers, Org. Biomol. Chem., 2017, 15, 5877 DOI: 10.1039/C7OB01039G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements