Issue 5, 2017

Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex

Abstract

The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH3)2Cl]2(4,4′-methylenedianiline)}2+ (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3′–3′ direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins.

Graphical abstract: Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex

Supplementary files

Article information

Article type
Paper
Submitted
23 Febr. 2017
Accepted
11 Apr. 2017
First published
12 Apr. 2017

Metallomics, 2017,9, 494-500

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