Issue 6, 2017

Selenium enriched dietary supplement rapid screening method using XRF and DART-HRAM-MS for label verification

Abstract

Selenium is a biologically relevant trace element that is a common ingredient of commercially available dietary supplements. Label verification of dietary supplements enriched with selenium has been performed using liquid chromatography with inductively coupled plasma mass spectrometry (LC/ICP-MS) in research applications. While this method represents the gold standard, performing LC/ICP-MS analysis on dietary supplements can be cumbersome and comes with the cost of time, ultimately limiting the throughput of this technique. A rapid screening method would improve throughput and reduce the number of samples requiring the complete LC/ICP-MS characterization of selenium for dietary supplement label verification. A rapid screening method for the determination of total selenium using energy dispersive X-ray fluorescence (XRF) (limit of detection 4 μg g−1, limit of quantitation 30 μg g−1) and unbound “selenoamino acids” using direct analysis in real time high resolution accurate mass–mass spectrometry (DART-HRAM-MS) was successfully applied to 13 dietary supplements previously characterized by LC/ICP-MS. Overall, determining total and speciated selenium in enriched dietary supplements using the combined XRF/DART-HRAM-MS approach reduces the analysis time from several hours to less than 40 minutes per sample.

Graphical abstract: Selenium enriched dietary supplement rapid screening method using XRF and DART-HRAM-MS for label verification

Supplementary files

Article information

Article type
Technical Note
Submitted
04 Febr. 2017
Accepted
28 Marts 2017
First published
28 Marts 2017

J. Anal. At. Spectrom., 2017,32, 1196-1202

Selenium enriched dietary supplement rapid screening method using XRF and DART-HRAM-MS for label verification

T. A. Hanley, K. Kubachka, A. M. Taylor and S. E. Kern, J. Anal. At. Spectrom., 2017, 32, 1196 DOI: 10.1039/C7JA00050B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements