Issue 18, 2017

Glucose promoted facile reduction of azides to amines under aqueous alkaline conditions

Abstract

A quick and efficient method for the reduction of azides to amines in water using D-glucose and KOH as green reagents is reported. The protocol is simple, inexpensive, scalable, and can be applied to different aromatic, heteroaromatic and sulphonyl azides. A high level of chemoselectivity is observed for azide reduction in the presence of other reducible functionalities like cyano, nitro, ether, ketone, amide and acid. The reaction gets completed in a short time (5–20 minutes), and furnishes the amines in high yield (85–99%). Unlike conventional hydrogenations, this reduction protocol does not require any metal catalyst, elaborate experimental setup or use of high-pressure equipment.

Graphical abstract: Glucose promoted facile reduction of azides to amines under aqueous alkaline conditions

Supplementary files

Article information

Article type
Communication
Submitted
30 Maijs 2017
Accepted
27 Jūl. 2017
First published
27 Jūl. 2017

Green Chem., 2017,19, 4268-4271

Glucose promoted facile reduction of azides to amines under aqueous alkaline conditions

N. Chandna, F. Kaur, S. Kumar and N. Jain, Green Chem., 2017, 19, 4268 DOI: 10.1039/C7GC01593C

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