Issue 53, 2017

Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid

Abstract

Polypeptides containing 2-aminoisobutyric acid (Aib) units as an unnatural amino acid residue were synthesized by papain-catalyzed chemoenzymatic polymerization of a tripeptide ethyl ester L-Ala-Aib-L-Ala-OEt in an aqueous medium. The Aib-containing polypeptide adopted an α-helix conformation in both the solid and solution phases, which was induced by the periodic Aib residue.

Graphical abstract: Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid

Supplementary files

Article information

Article type
Communication
Submitted
22 Apr. 2017
Accepted
03 Maijs 2017
First published
05 Maijs 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 7318-7321

Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid

K. Tsuchiya and K. Numata, Chem. Commun., 2017, 53, 7318 DOI: 10.1039/C7CC03095A

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