Issue 53, 2017

Micro- and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering

Abstract

A lack of electrical conductivity and structural organization in currently available biomaterial scaffolds limits their utility for generating physiologically representative models of functional cardiac tissue. Here we report on the development of scalable, graphene-functionalized topographies with anisotropic electrical conductivity for engineering the structural and functional phenotypes of macroscopic cardiac tissue constructs. Guided by anisotropic electroconductive and topographic cues, the tissue constructs displayed structural property enhancement in myofibrils and sarcomeres, and exhibited significant increases in the expression of cell–cell coupling and calcium handling proteins, as well as in action potential duration and peak calcium release.

Graphical abstract: Micro- and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering

Supplementary files

Article information

Article type
Communication
Submitted
23 Marts 2017
Accepted
14 Jūn. 2017
First published
14 Jūn. 2017

Chem. Commun., 2017,53, 7412-7415

Micro- and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering

A. S. T. Smith, H. Yoo, H. Yi, E. H. Ahn, J. H. Lee, G. Shao, E. Nagornyak, M. A. Laflamme, C. E. Murry and D. Kim, Chem. Commun., 2017, 53, 7412 DOI: 10.1039/C7CC01988B

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