Issue 1, 2017

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

Graphical abstract: Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

Supplementary files

Article information

Article type
Communication
Submitted
27 Sept. 2016
Accepted
23 Nov. 2016
First published
06 Dec. 2016

Biomater. Sci., 2017,5, 38-40

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

X. Luo, W. Wang, J. R. Dorkin, O. Veiseh, P. H. Chang, I. Abutbul-Ionita, D. Danino, R. Langer, D. G. Anderson and Y. Dong, Biomater. Sci., 2017, 5, 38 DOI: 10.1039/C6BM00683C

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