Issue 4, 2016

Glutathione boosting the cytotoxicity of a magnetic platinum(iv) nano-prodrug in tumor cells

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) are potential vehicles for targeted drug delivery and viable contrast agents for magnetic resonance imaging (MRI). A PtIV prodrug (HSPt) derived from functionalization of cisplatin with hydroxyl and succinate is conjugated with a poly(ethylene glycol) (PEG)-modified SPION for cancer therapy and monitoring of therapeutic responses. The relaxivity of HSPt–PEG-SPIONs is larger than that of commercial contrast agent Feridex, and a tumor-selective negative contrast is observed in MRI in a magnetic field. HSPt–PEG-SPIONs can be dissociated and reduced into PtII species by glutathione (GSH). Instead of forming DNA–Pt crosslinks, the reduced product induces direct DNA single- or double-strand breaks, which is uncommon for Pt drugs. The cytotoxicity of HSPt–PEG-SPIONs is positively correlated with the GSH level of tumor cells, which is opposite to the scenario of current Pt drugs. HSPt–PEG-SPIONs are as cytotoxic as cisplatin against cancer cells but are almost nontoxic towards normal cells. Since the mechanism of action of the nanocomposite is different from the established paradigm for Pt drugs, it may become a special theranostic agent for cancer treatment.

Graphical abstract: Glutathione boosting the cytotoxicity of a magnetic platinum(iv) nano-prodrug in tumor cells

Supplementary files

Article information

Article type
Edge Article
Submitted
27 Okt. 2015
Accepted
20 Janv. 2016
First published
20 Janv. 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 2864-2869

Glutathione boosting the cytotoxicity of a magnetic platinum(IV) nano-prodrug in tumor cells

Z. Zhu, Z. Wang, Y. Hao, C. Zhu, Y. Jiao, H. Chen, Y. Wang, J. Yan, Z. Guo and X. Wang, Chem. Sci., 2016, 7, 2864 DOI: 10.1039/C5SC04049C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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