Issue 50, 2016

PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma

Abstract

A thermogelling poly(ester urethane) comprising poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG) and poly(lactic acid) (PLA) blocks was synthesized. Drug release studies of the thermogel were carried out using paclitaxel (PTX). The release rate of the drug can be achieved by changing the concentration of the gel, greatly prolonging the release and elimination times to afford long-term effects. The thermogels showed very low toxicity on HEK293 cells. A nude mice model of hepatocellular carcinoma was developed and intratumoural injection of drug-loaded thermogel showed that PTX-loaded thermogel effectively inhibited the growth of tumours.

Graphical abstract: PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma

Supplementary files

Article information

Article type
Paper
Submitted
28 Marts 2016
Accepted
25 Apr. 2016
First published
26 Apr. 2016

RSC Adv., 2016,6, 44506-44513

PLA-based thermogel for the sustained delivery of chemotherapeutics in a mouse model of hepatocellular carcinoma

Y. Wu, H. Wang, Y. Qiu and X. J. Loh, RSC Adv., 2016, 6, 44506 DOI: 10.1039/C6RA08022G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements