Issue 3, 2016

A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations

Abstract

Fluorinated solvents like 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and trifluoroethanol (TFE) have recently emerged as a remarkable synthetic solution allowing challenging C–H activation reactions. A beneficial effect of these solvents on reactivity, as well as site- and stereoselectivity of various direct functionalization reactions has been observed. Moreover, several catalytic systems specifically require such fluorinated medium. This Highlight is devoted to showcasing the exceptional potential of fluorinated alcohols in the C–H activation field.

Graphical abstract: A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations

Article information

Article type
Highlight
Submitted
24 Nov. 2015
Accepted
18 Janv. 2016
First published
02 Febr. 2016

Org. Chem. Front., 2016,3, 394-400

Author version available

A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations

J. Wencel-Delord and F. Colobert, Org. Chem. Front., 2016, 3, 394 DOI: 10.1039/C5QO00398A

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