Issue 4, 2016

The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II

Abstract

Lasso peptides are fascinating natural products with a unique structural fold that can exhibit tremendous thermal stability. Here, we investigate factors responsible for the thermal stability of caulosegnin II. By employing X-ray crystallography, mutational analysis and molecular dynamics simulations, the ring residue proline 8 was proven to be crucial for thermal stability.

Graphical abstract: The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II

Supplementary files

Article information

Article type
Communication
Submitted
01 Febr. 2016
Accepted
05 Febr. 2016
First published
05 Febr. 2016
This article is Open Access
Creative Commons BY-NC license

Mol. BioSyst., 2016,12, 1106-1109

The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II

J. D. Hegemann, C. D. Fage, S. Zhu, K. Harms, F. S. Di Leva, E. Novellino, L. Marinelli and M. A. Marahiel, Mol. BioSyst., 2016, 12, 1106 DOI: 10.1039/C6MB00081A

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