Issue 1, 2016

Reverse Watson–Crick G–G base pair in G-quadruplex formation

Abstract

A stable intermediate dimeric G-rich form as a precursor of tetrameric G-quadruplex structures has been detected via MALDI-TOF spectrometry. Molecular dynamics simulation offered detailed insights at the atomic level, assigning reverse Watson–Crick G–G base pairing (not Hoogsteen) in the G-rich dimer. In support of this, cisplatin formed a stable adduct by binding to the dimeric G-rich structure, eliminating the possibility of G–G Hoogsteen hydrogen bond formation.

Graphical abstract: Reverse Watson–Crick G–G base pair in G-quadruplex formation

Supplementary files

Article information

Article type
Communication
Submitted
11 Sept. 2015
Accepted
09 Nov. 2015
First published
09 Nov. 2015

Mol. BioSyst., 2016,12, 18-22

Author version available

Reverse Watson–Crick G–G base pair in G-quadruplex formation

S. Mondal, J. Bhat, J. Jana, M. Mukherjee and S. Chatterjee, Mol. BioSyst., 2016, 12, 18 DOI: 10.1039/C5MB00611B

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