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Issue 23, 2016
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An inkjet printed, roll-coated digital microfluidic device for inexpensive, miniaturized diagnostic assays

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Abstract

The diagnosis of infectious disease is typically carried out at the point-of-care (POC) using the lateral flow assay (LFA). While cost-effective and portable, LFAs often lack the clinical sensitivity and specificity required for accurate diagnoses. In response to this challenge, we introduce a new digital microfluidic (DMF) platform fabricated using a custom inkjet printing and roll-coating process that is scalable to mass production. The performance of the new devices is on par with that of traditional DMF devices fabricated in a cleanroom, with a materials cost for the new devices of only US $0.63 per device. To evaluate the usefulness of the new platform, we performed a 13-step rubella virus (RV) IgG immunoassay on the inkjet printed, roll-coated devices, which yielded a limit of detection of 0.02 IU mL−1, well below the diagnostic cut-off of 10 IU mL−1 for RV infection and immunity. We propose that this represents a breakthrough for DMF, lowering the costs to a level such that the new platforms will be an attractive alternative to LFAs for the diagnosis of infectious disease at the POC.

Graphical abstract: An inkjet printed, roll-coated digital microfluidic device for inexpensive, miniaturized diagnostic assays

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Article information


Submitted
24 Aug. 2016
Accepted
21 Okt. 2016
First published
01 Nov. 2016

Lab Chip, 2016,16, 4560-4568
Article type
Paper

An inkjet printed, roll-coated digital microfluidic device for inexpensive, miniaturized diagnostic assays

C. Dixon, A. H. C. Ng, R. Fobel, M. B. Miltenburg and A. R. Wheeler, Lab Chip, 2016, 16, 4560
DOI: 10.1039/C6LC01064D

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