Issue 60, 2016

Immobilization of an artificial imine reductase within silica nanoparticles improves its performance

Abstract

Silica nanoparticles equipped with an artificial imine reductase display remarkable activity towards cyclic imine- and NAD+ reduction. The method, based on immobilization and protection of streptavidin on silica nanoparticles, shields the biotinylated metal cofactor against deactivation yielding over 46 000 turnovers in pure samples and 4000 turnovers in crude cellular extracts.

Graphical abstract: Immobilization of an artificial imine reductase within silica nanoparticles improves its performance

Supplementary files

Article information

Article type
Communication
Submitted
01 Jūn. 2016
Accepted
28 Jūn. 2016
First published
06 Jūl. 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 9462-9465

Immobilization of an artificial imine reductase within silica nanoparticles improves its performance

M. Hestericová, M. R. Correro, M. Lenz, P. F.-X. Corvini, P. Shahgaldian and T. R. Ward, Chem. Commun., 2016, 52, 9462 DOI: 10.1039/C6CC04604E

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