Issue 27, 2016

Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

Abstract

Design, synthesis and single-crystal conformations of hybrid triple-stranded β-sheets composed of E-vinylogous residues are reported. Restricting conformational flexibility of β-strands through the insertion of carbon–carbon double bonds at facing positions leads to increased peptide crystallinity, which allowed unambiguous structural characterization of three-stranded β-sheets. This strategy can be further explored for the design of functional β-sheets.

Graphical abstract: Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

  • This article is part of the themed collection: Foldamers

Supplementary files

Article information

Article type
Communication
Submitted
06 Janv. 2016
Accepted
04 Marts 2016
First published
04 Marts 2016

Chem. Commun., 2016,52, 4938-4941

Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

A. Bandyopadhyay, R. Misra and H. N. Gopi, Chem. Commun., 2016, 52, 4938 DOI: 10.1039/C6CC00127K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements