Issue 91, 2015

Polyhydroxylated GdDTPA-derivatives as high relaxivity magnetic resonance imaging contrast agents

Abstract

The search for new MRI agents endowed with high relaxivity at the magnetic field strength of clinical scanners (1.5–3 T) is still receiving great attention from researchers involved in the development of new probes. Such Gd(III) complexes should combine a fast inner-sphere water exchange rate (kex) with an enhanced contribution from water molecules in the second and outer coordination spheres. In the present work, dendrimeric-like structures were synthesized by coupling diethylenetriaminepentaacetic acid (DTPA) and its mono-methylphosphonic derivative (P-DTPA) with two differently branched, highly hydrophilic, gluconyl moieties. A 1H and 17O NMR relaxometric study on the corresponding Gd(III) complexes reveals that the Gd-P-DTPA-polyol complex displays very high relaxivities (around 20 mM−1 s−1 at 298 K) over the 0.5–3 T range of field strengths as a result of a fast kex and the presence of a strong second sphere contribution.

Graphical abstract: Polyhydroxylated GdDTPA-derivatives as high relaxivity magnetic resonance imaging contrast agents

Supplementary files

Article information

Article type
Paper
Submitted
29 Jūl. 2015
Accepted
28 Aug. 2015
First published
28 Aug. 2015

RSC Adv., 2015,5, 74734-74743

Polyhydroxylated GdDTPA-derivatives as high relaxivity magnetic resonance imaging contrast agents

L. Tei, A. Barge, M. Galli, R. Pinalli, L. Lattuada, E. Gianolio and S. Aime, RSC Adv., 2015, 5, 74734 DOI: 10.1039/C5RA15071J

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