Issue 65, 2015

Stereoselective synthesis of 3-amino-2-oxindoles from isatin imines: new scaffolds for bioactivity evaluation

Abstract

3-Substituted-3-aminooxindoles have attracted the attention of organic and medicinal chemists because these motifs constitute the core structure of a number of natural products and drug candidates. The catalytic potential of chiral organocatalysts and metal catalysts has been successfully exploited for the synthesis of enantioenriched 3-amino-2-oxindoles via the addition of various nucleophiles to isatin imines. This review focuses on the catalytic asymmetric synthesis of chiral 3-amino-3-substituted-2-oxindoles.

Graphical abstract: Stereoselective synthesis of 3-amino-2-oxindoles from isatin imines: new scaffolds for bioactivity evaluation

Article information

Article type
Review Article
Submitted
17 Apr. 2015
Accepted
21 Maijs 2015
First published
26 Maijs 2015

RSC Adv., 2015,5, 52481-52496

Stereoselective synthesis of 3-amino-2-oxindoles from isatin imines: new scaffolds for bioactivity evaluation

J. Kaur, S. S. Chimni, S. Mahajan and A. Kumar, RSC Adv., 2015, 5, 52481 DOI: 10.1039/C5RA06969F

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