Issue 45, 2015

Shape-controlled gold nanoparticles supported on MoS2 nanosheets: synergistic effect of thionine and MoS2 and their application for electrochemical label-free immunosensing

Abstract

Herein, a facile approach for shape-controlled gold nanoparticle (AuNP) decorated thionine–MoS2 nanocomposites (AuNP–Thi–MoS2) had been reported by using the synergistic effect of MoS2 and Thi. Thi was not only used as an electrochemical indicator, but also as a reducing agent to tune the resulting morphologies of AuNPs. With the ratio of MoS2/Thi decreasing, the shapes of AuNPs changed from spherical, triangle, clover-like to flower-like nanostructures. TEM, XRD and XPS were employed to characterize the formation and chemical composition of AuNP–Thi–MoS2 nanocomposites. On the basis of synthesis, a MoS2-based label-free electrochemical immunosensor had been designed to detect carcino-embryonic antigen (CEA). The proposed immunosensor could detect as low as 0.52 pg mL−1 CEA with excellent selectivity. Moreover, the expected immunosensor showed high stability and excellent reproducibility, which could detect CEA in human serum with satisfactory results. Therefore, the AuNP–Thi–MoS2 nanocomposites may be considered as a candidate sensing platform for fabrication of simple, label-free and ultrasensitive electrochemical sensors.

Graphical abstract: Shape-controlled gold nanoparticles supported on MoS2 nanosheets: synergistic effect of thionine and MoS2 and their application for electrochemical label-free immunosensing

Supplementary files

Article information

Article type
Paper
Submitted
19 Aug. 2015
Accepted
15 Okt. 2015
First published
20 Okt. 2015

Nanoscale, 2015,7, 19129-19135

Shape-controlled gold nanoparticles supported on MoS2 nanosheets: synergistic effect of thionine and MoS2 and their application for electrochemical label-free immunosensing

S. Su, M. Zou, H. Zhao, C. Yuan, Y. Xu, C. Zhang, L. Wang, C. Fan and L. Wang, Nanoscale, 2015, 7, 19129 DOI: 10.1039/C5NR05614D

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