Issue 4, 2015

Chiral ureas and thioureas supported on polystyrene for enantioselective aza-Henry reactions under solvent-free conditions

Abstract

Novel bifunctional ureas and thioureas immobilized on sulfonylpolystyrene have been prepared as recoverable and reusable organocatalysts and have been used in the stereoselective aza-Henry reaction under solvent-free conditions. The activity and stereoselection of the catalysts are dependent on the length of the tether bridging the active site and the polymer, the catalyst derived from 1,6-hexane diamine being the best one. It has also been demonstrated that the supported catalysts are more effective than the homologous soluble catalysts.

Graphical abstract: Chiral ureas and thioureas supported on polystyrene for enantioselective aza-Henry reactions under solvent-free conditions

Supplementary files

Article information

Article type
Paper
Submitted
18 Dec. 2014
Accepted
21 Janv. 2015
First published
22 Janv. 2015

Green Chem., 2015,17, 2217-2225

Author version available

Chiral ureas and thioureas supported on polystyrene for enantioselective aza-Henry reactions under solvent-free conditions

R. Pedrosa, J. M. Andrés, D. P. Ávila, M. Ceballos and R. Pindado, Green Chem., 2015, 17, 2217 DOI: 10.1039/C4GC02474E

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