Issue 14, 2015

Fluorometric imaging methods for palladium and platinum and the use of palladium for imaging biomolecules

Abstract

Neither palladium nor platinum is an endogenous biological metal. Imaging palladium in biological samples, however, is becoming increasingly important because bioorthogonal organometallic chemistry involves palladium catalysis. In addition to being an imaging target, palladium has been used to fluorometrically image biomolecules. In these cases, palladium species are used as imaging-enabling reagents. This review article discusses these fluorometric methods. Platinum-based drugs are widely used as anticancer drugs, yet their mechanism of action remains largely unknown. We discuss fluorometric methods for imaging or quantifying platinum in cells or biofluids. These methods include the use of chemosensors to directly detect platinum, fluorescently tagging platinum-based drugs, and utilizing post-labeling to elucidate distribution and mode of action.

Graphical abstract: Fluorometric imaging methods for palladium and platinum and the use of palladium for imaging biomolecules

Article information

Article type
Review Article
Submitted
27 Sept. 2014
First published
23 Febr. 2015

Chem. Soc. Rev., 2015,44, 4769-4791

Fluorometric imaging methods for palladium and platinum and the use of palladium for imaging biomolecules

M. P. Tracey, D. Pham and K. Koide, Chem. Soc. Rev., 2015, 44, 4769 DOI: 10.1039/C4CS00323C

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