Issue 25, 2015

Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin

Abstract

Polycyclic tetramate macrolactams (PTMs) are a structurally, biomedically and biosynthetically intriguing class of bacterial metabolites. By combining parts of the machineries of different PTM biosynthetic pathways, we demonstrate for the first time the substrate promiscuity of a class of PTM tailoring enzymes, thereby facilitating the (bio)synthesis of butremycin.

Graphical abstract: Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin

Supplementary files

Article information

Article type
Communication
Submitted
29 Janv. 2015
Accepted
20 Febr. 2015
First published
20 Febr. 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 5334-5336

Author version available

Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin

C. Greunke, J. Antosch and T. A. M. Gulder, Chem. Commun., 2015, 51, 5334 DOI: 10.1039/C5CC00843C

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