Issue 23, 2015

Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis

Abstract

Understanding and probing small molecule uptake in cells is challenging, requiring sterically large chemical labels, or radioactive isotopes. Here, the uptake of deuterated sugars by Mycobacterium smegmatis, a non-pathogenic model of Mycobacterium tuberculosis, has been investigated using ion-beam (nuclear reaction) analysis demonstrating a new technique for label-free nutrient acquisition measurement.

Graphical abstract: Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis

Supplementary files

Article information

Article type
Communication
Submitted
01 Dec. 2014
Accepted
12 Febr. 2015
First published
12 Febr. 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 4838-4841

Author version available

Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis

R. Lowery, M. I. Gibson, R. L. Thompson and E. Fullam, Chem. Commun., 2015, 51, 4838 DOI: 10.1039/C4CC09588J

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