Issue 20, 2015

Collision cross sections of high-mannose N-glycans in commonly observed adduct states – identification of gas-phase conformers unique to [M − H] ions

Abstract

We report collision cross sections (CCS) of high-mannose N-glycans as [M + Na]+, [M + K]+, [M + H]+, [M + Cl], [M + H2PO4] and [M − H] ions, measured by drift tube (DT) ion mobility-mass spectrometry (IM-MS) in helium and nitrogen gases. Further analysis using traveling wave (TW) IM-MS reveal the existence of distinct conformers exclusive to [M − H] ions.

Graphical abstract: Collision cross sections of high-mannose N-glycans in commonly observed adduct states – identification of gas-phase conformers unique to [M − H]− ions

Supplementary files

Article information

Article type
Communication
Submitted
01 Jūn. 2015
Accepted
06 Jūl. 2015
First published
07 Jūl. 2015
This article is Open Access
Creative Commons BY license

Analyst, 2015,140, 6799-6803

Author version available

Collision cross sections of high-mannose N-glycans in commonly observed adduct states – identification of gas-phase conformers unique to [M − H] ions

W. B. Struwe, J. L. Benesch, D. J. Harvey and K. Pagel, Analyst, 2015, 140, 6799 DOI: 10.1039/C5AN01092F

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