Issue 7, 2015

Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors

Abstract

Intracellular redox potential is a highly regulated cellular characteristic and is critically involved in maintaining cellular health and function. The dysregulation of redox potential can result in the initiation and progression of numerous diseases. Redox potential is determined by the balance of oxidants and reductants in the cell and also by pH. For this reason a technique for quantitative measurement of intracellular redox potential and pH is highly desirable. In this paper we demonstrate how surface enhanced Raman scattering (SERS) nanosensors can be used for multiplexed measurement of both pH and redox potential in live single cells.

Graphical abstract: Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors

Supplementary files

Article information

Article type
Paper
Submitted
23 Dec. 2014
Accepted
11 Febr. 2015
First published
20 Febr. 2015
This article is Open Access
Creative Commons BY license

Analyst, 2015,140, 2330-2335

Author version available

Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors

L. E. Jamieson, A. Jaworska, J. Jiang, M. Baranska, D. J. Harrison and C. J. Campbell, Analyst, 2015, 140, 2330 DOI: 10.1039/C4AN02365J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements