Issue 86, 2014

Divergent reaction: metal & oxidant free direct C–H aryloxylation and hydride free formal reductive N-benzylation of N-heterocycles

Abstract

Metal, oxidant and other additive-free novel methods for direct C–H aryloxylation of aliphatic amines are developed. In the presence of excess amine, the course of the reaction was diverted, producing various arylmethylamines via hydride-free formal reductive amination. Involvement of a quinone methide intermediate was revealed from mechanistic studies.

Graphical abstract: Divergent reaction: metal & oxidant free direct C–H aryloxylation and hydride free formal reductive N-benzylation of N-heterocycles

Supplementary files

Article information

Article type
Communication
Submitted
28 Maijs 2014
Accepted
15 Sept. 2014
First published
15 Sept. 2014

RSC Adv., 2014,4, 46214-46217

Divergent reaction: metal & oxidant free direct C–H aryloxylation and hydride free formal reductive N-benzylation of N-heterocycles

S. Mahato, M. A. Haque, S. Dwari and C. K. Jana, RSC Adv., 2014, 4, 46214 DOI: 10.1039/C4RA05045B

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