Issue 40, 2014

A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

Abstract

Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)–amyloid-β (Aβ) over Zn(II)–Aβ.

Graphical abstract: A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

Supplementary files

Article information

Article type
Communication
Submitted
06 Nov. 2013
Accepted
20 Nov. 2013
First published
10 Dec. 2013

Chem. Commun., 2014,50, 5301-5303

Author version available

A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

M. G. Savelieff, Y. Liu, R. R. P. Senthamarai, K. J. Korshavn, H. J. Lee, A. Ramamoorthy and M. H. Lim, Chem. Commun., 2014, 50, 5301 DOI: 10.1039/C3CC48473D

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