Issue 40, 2014

Catalytic intermolecular β-C–H alkenylation of α-enamino-ketones with simple alkynes

Abstract

A unique strategy to synthesize β-alkenylated α-enamino-ketones via catalytic C–H/alkyne coupling is described. The slow addition of alkyne substrates and the use of NaI as an additive play key roles in controlling the alkyne insertion. Replacement of the pyridyl group with carbamates was also developed. This method allows for rapid synthesis of highly functionalized vinyl-substituted enamino-ketones.

Graphical abstract: Catalytic intermolecular β-C–H alkenylation of α-enamino-ketones with simple alkynes

Supplementary files

Article information

Article type
Communication
Submitted
02 Okt. 2013
Accepted
04 Nov. 2013
First published
05 Nov. 2013

Chem. Commun., 2014,50, 5230-5232

Catalytic intermolecular β-C–H alkenylation of α-enamino-ketones with simple alkynes

Z. Wang, B. J. Reinus and G. Dong, Chem. Commun., 2014, 50, 5230 DOI: 10.1039/C3CC47556E

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