Issue 40, 2014

2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation

Abstract

2-Sulfonyl-oxetanes have been prepared, affording non-planar structures with desirable physicochemical properties for fragment based drug discovery. The oxetane motif was formed by an intramolecular C–C bond formation. The fragments were further functionalised via organometallic intermediates at the intact oxetane and aromatic rings.

Graphical abstract: 2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation

Supplementary files

Article information

Article type
Communication
Submitted
23 Aug. 2013
Accepted
24 Okt. 2013
First published
25 Okt. 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 5203-5205

2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation

K. F. Morgan, I. A. Hollingsworth and J. A. Bull, Chem. Commun., 2014, 50, 5203 DOI: 10.1039/C3CC46450D

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