Issue 5, 2011

The frequently overlooked importance of solvent in free radical syntheses

Abstract

This tutorial review is designed to dispel the myth, still believed by many synthetic organic chemists, that radical-based syntheses are free from significant solvent effects. However, many synthetically valuable radical reactions do exhibit large kinetic solvent effects. It is therefore important to select the solvent for any proposed radical synthesis with considerable care if good product yields are to be achieved.

Graphical abstract: The frequently overlooked importance of solvent in free radical syntheses

Article information

Article type
Tutorial Review
Submitted
08 Janv. 2011
First published
22 Febr. 2011

Chem. Soc. Rev., 2011,40, 2157-2163

The frequently overlooked importance of solvent in free radical syntheses

G. Litwinienko, A. L. J. Beckwith and K. U. Ingold, Chem. Soc. Rev., 2011, 40, 2157 DOI: 10.1039/C1CS15007C

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