Issue 45, 2005

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Abstract

Polyoxometalates (PMs) as discrete metal-oxide cluster anions comprise a versatile class of inorganic, anionic clusters that have a wide variety of structures, sizes, and a combination of metals, high solubility in water, and electrochemical activity. Recent investigation of anti-tumor, -viral, and -bacterial activities of PMs shows induced cell-apoptosis, inhibition of binding of virus to receptor, and the enhancement of β-lactam antibiotics as well as the inhibition of bacterial growth, respectively. PMs exemplified for each biological activity are discussed from the chemotherapeutic point of view for the establishment of a novel inorganic drug based on PMs.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Article information

Article type
Application
Submitted
01 Apr. 2005
Accepted
20 Jūn. 2005
First published
21 Jūl. 2005

J. Mater. Chem., 2005,15, 4773-4782

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

T. Yamase, J. Mater. Chem., 2005, 15, 4773 DOI: 10.1039/B504585A

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