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Issue 18, 2001
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Novel chiral imidazole cyclophane receptors: synthesis and enantioselective recognition for

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Abstract

Novel chiral imidazole cyclophane receptors were synthesized by highly selective N-alkylation of the imidazolyl 1N-position of the bridged histidine diester 2 with the dibromide in the presence of NaH; these receptors exhibit good chiral recognition toward the enantiomers of L- and D-amino acid derivatives (up to KD/KL = 3.52, ΔΔG0 = −3.11 kJ mol−1) in CHCl3 at 25.0 °C.

Graphical abstract: Novel chiral imidazole cyclophane receptors: synthesis and enantioselective recognition for amino acid derivatives

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Article information


Submitted
12 Apr. 2001
Accepted
31 Jūl. 2001
First published
23 Aug. 2001

Chem. Commun., 2001, 1816-1817
Article type
Communication

Novel chiral imidazole cyclophane receptors: synthesis and enantioselective recognition for amino acid derivatives

J. You, X. Yu, G. Zhang, Q. Xiang, J. Lan and R. Xie, Chem. Commun., 2001, 1816
DOI: 10.1039/B103325P

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