Issue 29, 2024

Charge-reversal polymeric nanomodulators for ferroptosis-enhanced photodynamic therapy

Abstract

The clinical application of photodynamic therapy (PDT) has some limitations including poor tumor targeting properties, a high reductive tumor microenvironment, and inefficient activation of single cell death machinery. We herein report pH-sensitive polymeric nanomodulators (NBS-PDMC NPs) for ferroptosis-enhanced photodynamic therapy. NBS-PDMC NPs were constructed using a positively charged type-I photosensitizer (NBS) coordinated with a demethylcantharidin (DMC)-decorated block copolymer via electrostatic interactions. NBS-PDMC NPs had a negative surface charge, which ensures their high stability in bloodstream circulation, while exposure to lysosomal acidic environments reverses their surface charge to positive for tumor penetration and the release of DMC and NBS. Under NIR light irradiation, NBS generated ROS to induce cell damage; in the meantime, DMC inhibited the expression of the GPX4 protein in tumor cells and promoted ferroptosis of tumor cells. This polymer design concept provides some novel insights into smart drug delivery and combinational action to amplify the antitumor effect.

Graphical abstract: Charge-reversal polymeric nanomodulators for ferroptosis-enhanced photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
25 Marts 2024
Accepted
06 Jūn. 2024
First published
11 Jūn. 2024

J. Mater. Chem. B, 2024,12, 7113-7121

Charge-reversal polymeric nanomodulators for ferroptosis-enhanced photodynamic therapy

X. Yang, M. He, Y. Li, T. Qiu, J. Zuo, Y. Jin, J. Fan, W. Sun and X. Peng, J. Mater. Chem. B, 2024, 12, 7113 DOI: 10.1039/D4TB00616J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements