Issue 20, 2024

Review of NIR-responsive ‘‘Smart’’ carriers for photothermal chemotherapy

Abstract

This review focuses on the versatile applications of near-infrared (NIR)-responsive smart carriers in biomedical applications, particularly drug delivery and photothermal chemotherapy. These carriers demonstrate multi-responsive theranostics capabilities, including pH-dependent drug release, targeted delivery of chemotherapeutics, heat-mediated drug release, and photothermal tumor damage. Biological samples are transparent to NIR light with a suitable wavelength, and therefore, NIR light is advantageous for deep-tissue penetration. It also generates sufficient heat in tissue samples, which is beneficial for on-demand NIR-responsive drug delivery in vivo systems. The development of biocompatible materials with sufficient NIR light absorption properties and drug-carrying functionality has shown tremendous growth in the last five years. Thus, this review offers insights into the current research development of NIR-responsive materials with therapeutic potential and prospects aimed at overcoming challenges to improve the therapeutic efficacy and safety in the dynamic field of NIR-responsive drug delivery.

Graphical abstract: Review of NIR-responsive ‘‘Smart’’ carriers for photothermal chemotherapy

Article information

Article type
Review Article
Submitted
20 Dec. 2023
Accepted
15 Apr. 2024
First published
16 Apr. 2024

J. Mater. Chem. B, 2024,12, 4785-4808

Review of NIR-responsive ‘‘Smart’’ carriers for photothermal chemotherapy

A. Karmakar, A. Silswal and A. L. Koner, J. Mater. Chem. B, 2024, 12, 4785 DOI: 10.1039/D3TB03004K

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