Issue 4, 2024

Augmentation of inductive effects through short range intramolecular hydrogen bonds for the improvement of cooperativity of trimeric rosettes

Abstract

Cooperativity in hydrogen bonds can be crucial for the stabilization of supramolecular systems. In this contribution, we propose a simple covalent modification within a pyrazole-based trimeric rosette that significantly improves its binding strength. Using dispersion-corrected density functional theory, at the BLYP-D3(BJ)/6-311++(d,p) level, we show how an intramolecular hydrogen bond acts as a bridge between an electron-donating group and an electron-withdrawing group by moving the electron density from one group to the other one through the sigma electron system. This effect strongly enhances the inductive ability of the substituents, and further increases the synergy of the cyclic trimer.

Graphical abstract: Augmentation of inductive effects through short range intramolecular hydrogen bonds for the improvement of cooperativity of trimeric rosettes

Supplementary files

Article information

Article type
Paper
Submitted
10 Janv. 2024
Accepted
23 Febr. 2024
First published
26 Febr. 2024

Mol. Syst. Des. Eng., 2024,9, 345-351

Augmentation of inductive effects through short range intramolecular hydrogen bonds for the improvement of cooperativity of trimeric rosettes

A. N. Petelski, T. Bundrea and N. M. Peruchena, Mol. Syst. Des. Eng., 2024, 9, 345 DOI: 10.1039/D4ME00008K

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