Issue 20, 2024

Solid-phase microextraction – a future technique in pharmacology and coating trends

Abstract

Traditional sample preparation techniques based on liquid–liquid extraction (LLE) or solid-phase extraction (SPE) often suffer from a major error due to the matrix effects caused by significant co-extraction of matrix components. The implementation of a modern extraction technique such as solid-phase microextraction (SPME) was aimed at reducing analysis time and the use of organic solvents, as well as eliminating pre-analytical and analytical errors. Solid-phase microextraction (SPME) is an innovative technique for extracting low molecular weight compounds (less than 1500 Da) from highly complex matrices, including biological matrices. It has a wide range of applications in various types of analysis including pharmaceutical, clinical, metabolomics and proteomics. SPME has a number of advantages over other extraction techniques. Among the most important are low environmental impact, the ability to sample and preconcentrate analytes in one step, simple automation, and the ability to extract multiple analytes simultaneously. It is expected to become, in the future, another method for cell cycle research. Numerous available literature sources prove that solid-phase microextraction can be a future technique in many scientific fields, including pharmaceutical sciences. This paper provides a literature review of trends in SPME coatings and pharmacological applications.

Graphical abstract: Solid-phase microextraction – a future technique in pharmacology and coating trends

Article information

Article type
Minireview
Submitted
31 Janv. 2024
Accepted
15 Apr. 2024
First published
15 Apr. 2024

Anal. Methods, 2024,16, 3164-3178

Solid-phase microextraction – a future technique in pharmacology and coating trends

A. Owczarzy, K. Kulig, K. Piordas, P. Piśla, P. Sarkowicz, W. Rogóż and M. Maciążek-Jurczyk, Anal. Methods, 2024, 16, 3164 DOI: 10.1039/D4AY00187G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements