Issue 11, 2023

Tailoring biomaterials for biomimetic organs-on-chips

Abstract

Organs-on-chips are microengineered microfluidic living cell culture devices with continuously perfused chambers penetrating to cells. By mimicking the biological features of the multicellular constructions, interactions among organs, vascular perfusion, physicochemical microenvironments, and so on, these devices are imparted with some key pathophysiological function levels of living organs that are difficult to be achieved in conventional 2D or 3D culture systems. In this technology, biomaterials are extremely important because they affect the microstructures and functionalities of the organ cells and the development of the organs-on-chip functions. Thus, herein, we provide an overview on the advances of biomaterials for the construction of organs-on-chips. After introducing the general components, structures, and fabrication techniques of the biomaterials, we focus on the studies of the functions and applications of these biomaterials in the organs-on-chips systems. Applications of the biomaterial-based organs-on-chips as alternative animal models for pharmaceutical, chemical, and environmental tests are described and highlighted. The prospects for exciting future directions and the challenges of biomaterials for realizing the further functionalization of organs-on-chips are also presented.

Graphical abstract: Tailoring biomaterials for biomimetic organs-on-chips

Article information

Article type
Review Article
Submitted
18 Maijs 2023
Accepted
14 Aug. 2023
First published
30 Aug. 2023

Mater. Horiz., 2023,10, 4724-4745

Tailoring biomaterials for biomimetic organs-on-chips

L. Sun, F. Bian, D. Xu, Y. Luo, Y. Wang and Y. Zhao, Mater. Horiz., 2023, 10, 4724 DOI: 10.1039/D3MH00755C

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