Issue 47, 2023

Recent advances and prospects of metal–organic frameworks in cancer therapies

Abstract

Metal–organic frameworks (MOFs) have been broadly applied in biomedical and other fields. MOFs have high porosity, a large comparative area, and good biostability and have attracted significant attention, especially in cancer therapies. This paper presents the latest applications of MOFs in chemodynamic therapy (CDT), sonodynamic therapy (SDT), photodynamic therapy (PDT), photothermal therapy (PTT), immunotherapy (IT), and combination therapy for breast cancer. A combination therapy is the combination of two different treatment modalities, such as CDT and PDT combination therapy, and is considered more effective than separate therapies. Herein, we have also discussed the advantages and disadvantages of combination therapy in the treatment of breast cancer. This paper aims to illustrate the potential of MOFs in new cancer therapeutic approaches, discuss their potential advantages, and provide some reflections on the latest research results.

Graphical abstract: Recent advances and prospects of metal–organic frameworks in cancer therapies

Article information

Article type
Perspective
Submitted
07 Aug. 2023
Accepted
26 Okt. 2023
First published
02 Nov. 2023

Dalton Trans., 2023,52, 17601-17622

Recent advances and prospects of metal–organic frameworks in cancer therapies

Z. Luo, Y. Sheng, C. Jiang, Y. Pan, X. Wang, A. Nezamzadeh-Ejhieh, J. Ouyang, C. Lu and J. Liu, Dalton Trans., 2023, 52, 17601 DOI: 10.1039/D3DT02543H

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