Issue 19, 2023

γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging

Abstract

An “AND” logic gate-based NIR fluorescent probe Si-NH2-Glu was developed based on novel meso-amine Si-Rhodamine, which combined γ-glutamyl transpeptidase and pH dual-responsive sites. The features of Si-NH2-Glu enable it to be applied in orthotopic tumor imaging and fluorescence-guided surgery.

Graphical abstract: γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging

Supplementary files

Article information

Article type
Communication
Submitted
02 Dec. 2022
Accepted
07 Febr. 2023
First published
08 Febr. 2023

Chem. Commun., 2023,59, 2795-2798

γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging

L. Zhang, H. Zhang, S. Chen, Y. Liu, X. Yang, F. Xiang, Y. Liu, K. Li and X. Yu, Chem. Commun., 2023, 59, 2795 DOI: 10.1039/D2CC06568A

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