Issue 3, 2022

Upconversion-nanoparticle-functionalized Janus micromotors for efficient detection of uric acid

Abstract

We report enzyme-powered upconversion-nanoparticle-functionalized Janus micromotors, which are prepared by immobilizing uricase asymmetrically onto the surface of silicon particles, to actively and rapidly detect uric acid. The asymmetric distribution of uricase on silicon particles allows the Janus micromotors to display efficient motion in urine under the propulsion of biocatalytic decomposition of uric acid and simultaneously detect uric acid based on the luminescence quenching effect of the UCNPs modified on the other side of SiO2. The efficient motion of the motors greatly enhances the interaction between UCNPs and the quenching substrate and improves the uric acid detection efficiency. Overall, such a platform using uric acid simultaneously as the detected substrate and motion fuel offers considerable promise for developing multifunctional micro/nanomotors for a variety of bioassay and biomedical applications.

Graphical abstract: Upconversion-nanoparticle-functionalized Janus micromotors for efficient detection of uric acid

Supplementary files

Article information

Article type
Communication
Submitted
20 Nov. 2021
Accepted
17 Dec. 2021
First published
20 Dec. 2021

J. Mater. Chem. B, 2022,10, 358-363

Upconversion-nanoparticle-functionalized Janus micromotors for efficient detection of uric acid

Y. Yuan, C. Gao, Z. Wang, J. Fan, H. Zhou, D. Wang, C. Zhou, B. Zhu and Q. He, J. Mater. Chem. B, 2022, 10, 358 DOI: 10.1039/D1TB02550C

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