Radical addition to the CC bond meets (1,n)-HAT: recent advances in the remote C(sp3)–H or C(sp2)–H functionalization of alkenes

Abstract

In recent years, remarkable advances in the functionalization of remote alkyl C(sp³)–H bonds or aldehydic C(sp²)–H bonds enabled by intermolecular radical addition to CC bond/(1,n)-HAT tandem sequences have been witnessed, which provided an efficient and versatile platform to construct structurally diverse and functionalized scaffolds with functional groups not only added across unsaturated CC double bonds, but also incorporated at the remote C(sp³)- or C(sp²)-positions from readily available alkenes with good to excellent site-selectivities. This review highlights the recent developments in this robust topic and the mechanistic scenarios governing these transformations.