Issue 19, 2022

Recent advances in the transition metal-free synthesis of heterocycles from α,β-unsaturated ketones

Abstract

Heterocyclic compounds are an inevitable part of our life. These important classes of molecules have a wide range of applications starting from life-sustaining drugs to agrochemicals. Numerous methods, including metal and non-metal mediated protocols, are documented to synthesise complex and straightforward heterocyclic entities. The metal-free protocols have more significance over the metal-catalyzed ones when the toxicity associated with the metal catalyst is considered. On the other hand, α,β-unsaturated ketones are essential building blocks in synthetic organic chemistry. The presence of multiple reaction sites makes conjugated carbonyls suitable substrates for constructing a vast array of heterocycles and carbocycles. Herein, the review's primary focus is to highlight the transition metal-free methodologies developed for synthesising various heterocyclic compounds by utilising α,β-unsaturated ketones as valuable synthons during the period of 2009 to 2020.

Graphical abstract: Recent advances in the transition metal-free synthesis of heterocycles from α,β-unsaturated ketones

Article information

Article type
Review Article
Submitted
21 Febr. 2022
Accepted
25 Maijs 2022
First published
26 Maijs 2022

Org. Chem. Front., 2022,9, 5306-5357

Recent advances in the transition metal-free synthesis of heterocycles from α,β-unsaturated ketones

K. T. Ashitha, A. Krishna M. S., B. D. and S. B. Somappa, Org. Chem. Front., 2022, 9, 5306 DOI: 10.1039/D2QO00278G

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