Issue 14, 2022

Development of sustainable synthesis of glucuronic acid glycodendrimers using ball milling and microwave-assisted CuAAC reaction

Abstract

Two green strategies for copper-catalyzed azide–alkyne cycloaddition reaction based on two activation pathways, solvent free mechanochemistry and microwave irradiation using a recycable biosolvent, are reported for the synthesis of glucuronic acid glycodendrimers with good conversions (99%), the MW pathway being the ideal tool (90% yield in 90 min).

Graphical abstract: Development of sustainable synthesis of glucuronic acid glycodendrimers using ball milling and microwave-assisted CuAAC reaction

Supplementary files

Article information

Article type
Communication
Submitted
24 Dec. 2021
Accepted
08 Marts 2022
First published
08 Marts 2022

New J. Chem., 2022,46, 6389-6393

Development of sustainable synthesis of glucuronic acid glycodendrimers using ball milling and microwave-assisted CuAAC reaction

C. García-Oliva, A. Merchán, A. Perona, P. Hoyos, Á. Rumbero and M. J. Hernáiz, New J. Chem., 2022, 46, 6389 DOI: 10.1039/D1NJ06132A

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