Issue 4, 2022

Formation of pharmaceutical salts and cocrystals via vapour-assisted tumbling (VAT) – a solvent efficient process

Abstract

Crystallisations on both the academic and industrial scale often use large volumes of solvent. In order to decrease the environmental impact of such processes, new techniques must be discovered that increase the efficiency of the solvents used. Introduced here is a process that combines repurposed industry standard hardware and aspects of mechanochemistry to produce a technique we call “Vapour Assisted Tumbling” (VAT). Pharmaceutical and well-known cocrystals and salts were formed by tumbling the coformers in an atmosphere of vaporised solvent, in this study, methanol (MeOH). This was done inside a custom built analogue of an industrial rotary cone dryer (RCD). It was found that a desired solid form could be obtained as monitored by powder X-ray diffraction and differential scanning calorimetry. By repurposing industrial RCDs, it is feasible that solid forms can be crystallised with both minimal and reusable/recyclable solvent – drastically lowering the environmental impact of such transformations.

Graphical abstract: Formation of pharmaceutical salts and cocrystals via vapour-assisted tumbling (VAT) – a solvent efficient process

Supplementary files

Article information

Article type
Paper
Submitted
06 Okt. 2021
Accepted
02 Dec. 2021
First published
02 Dec. 2021

Green Chem., 2022,24, 1505-1514

Formation of pharmaceutical salts and cocrystals via vapour-assisted tumbling (VAT) – a solvent efficient process

A. J. Stirk, F. E. S. Souza, J. Gerster, F. M. Mir, A. Karadeolian and A. W. Rey, Green Chem., 2022, 24, 1505 DOI: 10.1039/D1GC03683A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements