Issue 95, 2022

Pd(ii)-catalyzed annulation of terminal alkynes with 2-pyridinyl-substituted p-quinone methides: direct access to indolizines

Abstract

A Pd-catalyzed direct method has been developed to access 1,3-disubstituted indolizines. This reaction proceeds through a regiospecific annulation of terminal alkynes with 2-pyridinyl-substituted p-quinone methides and, in most of the cases, the desired 1,3-disubstituted indolizines were obtained in moderate to good isolated yields. The control experiments suggested that the reaction does proceed through a substrate-controlled regiospecific formal [3 + 2]-annulation pathway.

Graphical abstract: Pd(ii)-catalyzed annulation of terminal alkynes with 2-pyridinyl-substituted p-quinone methides: direct access to indolizines

Supplementary files

Article information

Article type
Communication
Submitted
06 Aug. 2022
Accepted
02 Nov. 2022
First published
03 Nov. 2022

Chem. Commun., 2022,58, 13238-13241

Pd(II)-catalyzed annulation of terminal alkynes with 2-pyridinyl-substituted p-quinone methides: direct access to indolizines

F. Ahmad, P. K. Ranga, Y. A. Pankhade, S. Fatma, A. Gouda and R. V. Anand, Chem. Commun., 2022, 58, 13238 DOI: 10.1039/D2CC04395E

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