Issue 75, 2022

Phosphine-mediated three-component bioconjugation of amino- and azidosaccharides in ionic liquids

Abstract

Bioconjugation of carbohydrates has been a challenging task because of their chemical, functional, and structural diversities, and no single chemical modification tool can be universally applicable to all the target substrates in different environments. In this report, we have developed a bioconjugation strategy for labeling of carbohydrate derivatives through a phosphine-mediated three-component coupling reaction in an ionic liquid medium.

Graphical abstract: Phosphine-mediated three-component bioconjugation of amino- and azidosaccharides in ionic liquids

Supplementary files

Article information

Article type
Communication
Submitted
18 Jūl. 2022
Accepted
18 Aug. 2022
First published
19 Aug. 2022

Chem. Commun., 2022,58, 10568-10571

Phosphine-mediated three-component bioconjugation of amino- and azidosaccharides in ionic liquids

Y. D. Hall, C. P. Uzoewulu, Z. M. Nizam, S. Ishizawa, H. M. El-Shaffey and J. Ohata, Chem. Commun., 2022, 58, 10568 DOI: 10.1039/D2CC04013A

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