Issue 30, 2022

Recent developments in DNA-based mechanical nanodevices

Abstract

Cellular processes and functions can be regulated by mechanical forces. Nanodevices that can measure and manipulate these forces are critical tools in chemical and cellular biology. Synthetic DNA oligonucleotides have been used to develop a wide range of powerful nanodevices due to their programmable nature and precise and predictable self-assembly. In recent years, various types of DNA-based mechanical nanodevices have been engineered for studying molecular-level forces. With the help of these nanodevices, our understanding of cellular responses to physical forces has been significantly advanced. In this article, we have reviewed some recent developments in DNA-based mechanical sensors and regulators for application in the characterization of cellular biomechanics and the manipulation of cellular morphology, motion and other functions. The design principles discussed in this article can be further used to inspire other types of powerful DNA-based mechanical nanodevices.

Graphical abstract: Recent developments in DNA-based mechanical nanodevices

Article information

Article type
Feature Article
Submitted
17 Janv. 2022
Accepted
08 Marts 2022
First published
08 Marts 2022

Chem. Commun., 2022,58, 4700-4710

Recent developments in DNA-based mechanical nanodevices

Q. Tian, P. Keshri and M. You, Chem. Commun., 2022, 58, 4700 DOI: 10.1039/D2CC00302C

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