Issue 9, 2022

Photoredox catalyzed C–H trifluoroethylamination of heteroarenes

Abstract

The first C–H trifluoroethylamination of heteroarenes with previously unknown N-trifluoroethyl hydroxylamine reagents was achieved under photoredox catalyzed conditions. In the presence of an iridium(III) photoredox catalyst, a variety of heteroarenes, such as indoles, benzofurans, and benzothiophenes, were smoothly converted to the trifluoroethylaminated products in moderate to high yields and with excellent regioselectivity.

Graphical abstract: Photoredox catalyzed C–H trifluoroethylamination of heteroarenes

Supplementary files

Article information

Article type
Communication
Submitted
29 Nov. 2021
Accepted
20 Dec. 2021
First published
05 Janv. 2022

Chem. Commun., 2022,58, 1346-1349

Photoredox catalyzed C–H trifluoroethylamination of heteroarenes

J. Wang, S. Liu, Y. Huang, X. Xu and F. Qing, Chem. Commun., 2022, 58, 1346 DOI: 10.1039/D1CC06688A

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