Issue 45, 2021

131I-Labeled gold nanoframeworks for radiotherapy-combined second near-infrared photothermal therapy of cancer

Abstract

Photothermal therapy (PTT) has shown great promise for cancer treatment via light-triggered heat generation, while the anticancer efficacy of sole PTT is often limited. In this study, we report the use of radionuclide 131I-labeled gold nanoframeworks (131I-AuNFs) for radiotherapy-combined second near-infrared (NIR-II) PTT of breast cancer. AuNFs synthesized via a simple reduction approach are surface functionalized with polydopamine and poly(ethylene glycol), followed by labeling with 131I. The formed 131I-AuNFs with a high photothermal conversion efficacy and stable radioactivity can effectively accumulate into subcutaneous 4T1 mouse models as confirmed by in vivo single photon emission computed tomography (SPECT) imaging. Upon 1064 nm laser irradiation of tumors, local heat is generated for NIR-II PTT, which combines with radiotherapy to achieve a much higher therapeutic efficacy relative to sole treatment. As such, 131I-AuNFs-mediated radiotherapy-combined NIR-II PTT results in the effective inhibition of the growth of subcutaneous tumors. This study thus provides a facile nanoplatform for effective combination cancer therapy.

Graphical abstract: 131I-Labeled gold nanoframeworks for radiotherapy-combined second near-infrared photothermal therapy of cancer

Supplementary files

Article information

Article type
Paper
Submitted
27 Sept. 2021
Accepted
15 Okt. 2021
First published
15 Okt. 2021

J. Mater. Chem. B, 2021,9, 9316-9323

131I-Labeled gold nanoframeworks for radiotherapy-combined second near-infrared photothermal therapy of cancer

D. Cheng, J. Gong, P. Wang, J. Zhu, N. Yu, J. Zhao, Q. Zhang and J. Li, J. Mater. Chem. B, 2021, 9, 9316 DOI: 10.1039/D1TB02115J

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